abstract：:The expression of cognitive symptoms associated with HIV varies over time and across individuals. This pattern may reflect transient contextual factors, including the degree of effort exerted by individuals undergoing cognitive testing. The present study examined whether effort corresponds to the expression of persist...

journal_title：Journal of neurovirology

authors： Paul R,Rhee G,Baker LM,Vaida F,Cooley SA,Ances BM

更新日期：2017-10-01 00:00:00

abstract：:Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly...

journal_title：Journal of neurovirology

authors： Oliveira BRSM,Vieira FV,de S Vieira D,da Silva SEL,Gameiro R,Flores EF,Cardoso TC

更新日期：2017-10-01 00:00:00

abstract：:Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV inf...

journal_title：Journal of neurovirology

authors： Armstrong NM,Surkan PJ,Treisman GJ,Sacktor NC,Irwin MR,Teplin LA,Stall R,Martin EM,Becker JT,Munro C,Levine AJ,Jacobson LP,Abraham AG

更新日期：2017-08-01 00:00:00

abstract：:Here, we report a patient who developed diplopia secondary to a right cranial nerve III and IV palsy, as well as fever and headache. Cerebrospinal fluid analysis (CSF) showed high varicella-zoster virus (VZV)-DNA viral load (>300,000,000 copies/ml). VZV antibodies in CSF was ≥1:16. Diagnosis of neurological reactivati...

journal_title：Journal of neurovirology

authors： Del Borgo C,Belvisi V,Valli MB,Currà A,Pozzetto I,Sepe M,Mastroianni CM

更新日期：2017-08-01 00:00:00

abstract：:The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133...

journal_title：Journal of neurovirology

authors： Lake JE,Popov M,Post WS,Palella FJ,Sacktor N,Miller EN,Brown TT,Becker JT

更新日期：2017-06-01 00:00:00

abstract：:Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neu...

journal_title：Journal of neurovirology

authors： Pérez-Santiago J,De Oliveira MF,Var SR,Day TRC,Woods SP,Gianella S,Mehta SR

更新日期：2017-04-01 00:00:00

abstract：:Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient c...

journal_title：Journal of neurovirology

authors： Paul RH,Phillips S,Hoare J,Laidlaw DH,Cabeen R,Olbricht GR,Su Y,Stein DJ,Engelbrecht S,Seedat S,Salminen LE,Baker LM,Heaps J,Joska J

更新日期：2017-04-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HANDs) continue to be common and are associated with increased morbidity and mortality. However, the underlying mechanisms in the combination antiretroviral therapy (cART) era are not fully understood. Interferon alpha (IFNα) is an antiviral cytokine found to be elevated in the...

journal_title：Journal of neurovirology

authors： Anderson AM,Lennox JL,Mulligan MM,Loring DW,Zetterberg H,Blennow K,Kessing C,Koneru R,Easley K,Tyor WR

更新日期：2017-02-01 00:00:00

abstract：:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for oth...

journal_title：Journal of neurovirology

authors： Crossley KM,Agnihotri S,Chaganti J,Rodriguez ML,McNally LP,Venna N,Turbett SE,Gutman M,Morey A,Koralnik IJ,Brew BJ

更新日期：2016-08-01 00:00:00

abstract：:It is increasingly evident that the human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has a unique role in neuropathogenesis. Its ability to induce G2/M arrest coupled with its capacity to increase viral gene transcription gives it a unique role in sustaining viral replication and aiding in the establi...

journal_title：Journal of neurovirology

authors： James T,Nonnemacher MR,Wigdahl B,Krebs FC

更新日期：2016-08-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macrophages. Lack of remyelination has been attributed to insufficient pro...

journal_title：Journal of neurovirology

authors： Benner B,Martorell AJ,Mahadevan P,Najm FJ,Tesar PJ,Freundt EC

更新日期：2016-06-01 00:00:00

abstract：:HIV viral proteins within the central nervous system are associated with the development of neurocognitive impairments in HIV-infected individuals. Dopamine transporter (DAT)-mediated dopamine transport is critical for normal dopamine homeostasis. Abnormal dopaminergic transmission has been implicated as a risk determ...

journal_title：Journal of neurovirology

authors： Zhu J,Yuan Y,Midde NM,Gomez AM,Sun WL,Quizon PM,Zhan CG

更新日期：2016-06-01 00:00:00

abstract：:Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the comb...

journal_title：Journal of neurovirology

authors： Seider TR,Gongvatana A,Woods AJ,Chen H,Porges EC,Cummings T,Correia S,Tashima K,Cohen RA

更新日期：2016-04-01 00:00:00

abstract：:Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairm...

journal_title：Journal of neurovirology

authors： Tang Z,Dong E,Liu J,Liu Z,Wei W,Wang B,Li H,Tian J

更新日期：2016-04-01 00:00:00

abstract：:Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p...

journal_title：Journal of neurovirology

authors： Day TR,Smith DM,Heaton RK,Franklin D,Tilghman MW,Letendre S,Jin H,Wu Z,Shi C,Yu X,Pérez-Santiago J

更新日期：2016-04-01 00:00:00

abstract：:Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. Ninety-five HIV+ adults clinically stable on combined antiretroviral treatment ...

journal_title：Journal of neurovirology

authors： Cysique LA,Dermody N,Carr A,Brew BJ,Teesson M

更新日期：2016-02-01 00:00:00

abstract：:Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracellular nucleotides concentration. NTPDase and 5'-nucleotidase are enzymes respon...

journal_title：Journal of neurovirology

authors： da Silva CB,Paim FC,Wolkmer P,Abdalla FH,Carvalho FB,Palma HH,Mello CB,Flores EF,Andrade CM,Lopes ST

更新日期：2015-10-01 00:00:00

abstract：:Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part o...

journal_title：Journal of neurovirology

authors： Shikuma CM,Bennett K,Ananworanich J,Gerschenson M,Teeratakulpisarn N,Jadwattanakul T,DeGruttola V,McArthur JC,Ebenezer G,Chomchey N,Praihirunkit P,Hongchookiat P,Mathajittiphun P,Nakamoto B,Hauer P,Phanuphak P,Phanuphak N

更新日期：2015-10-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both AKT (protein kinase ...

journal_title：Journal of neurovirology

authors： Carpenter D,Hsiang C,Jiang X,Osorio N,BenMohamed L,Jones C,Wechsler SL

更新日期：2015-10-01 00:00:00

abstract：:Our previous studies in an experimental model of rabies showed neuronal process degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion neurons infected with challenge virus standard (CVS)-11 strain of rabies virus (RABV) showed axonal swellings and reduced axonal growth wi...

journal_title：Journal of neurovirology

authors： Kammouni W,Wood H,Saleh A,Appolinario CM,Fernyhough P,Jackson AC

更新日期：2015-08-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1) invades the central nervous system (CNS) during acute infection which can result in HIV-associated neurocognitive disorders in up to 50% of patients, even in the presence of combination antiretroviral therapy (cART). Within the CNS, productive HIV-1 infection occurs in the p...

journal_title：Journal of neurovirology

authors： Churchill MJ,Cowley DJ,Wesselingh SL,Gorry PR,Gray LR

更新日期：2015-06-01 00:00:00

abstract：:On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australi...

journal_title：Journal of neurovirology

authors： Brew BJ,Robertson K,Wright EJ,Churchill M,Crowe SM,Cysique LA,Deeks S,Garcia JV,Gelman B,Gray LR,Johnson T,Joseph J,Margolis DM,Mankowski JL,Spencer B

更新日期：2015-06-01 00:00:00

abstract：:The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and ...

journal_title：Journal of neurovirology

authors： Daep CA,Muñoz-Jordán JL,Eugenin EA

更新日期：2014-12-01 00:00:00

abstract：:Previous animal studies have identified a C31S residue substitution in the C30C31 dicysteine motif of the Tat protein that is associated with reduced neurovirulence in clade C human immunodeficiency virus (HIV). However, clinical studies of patients infected with clade C HIV have reported significant levels of cogniti...

journal_title：Journal of neurovirology

authors： Paul RH,Joska JA,Woods C,Seedat S,Engelbrecht S,Hoare J,Heaps J,Valcour V,Ances B,Baker LM,Salminen LE,Stein DJ

更新日期：2014-12-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes app...

journal_title：Journal of neurovirology

authors： Ndhlovu LC,Umaki T,Chew GM,Chow DC,Agsalda M,Kallianpur KJ,Paul R,Zhang G,Ho E,Hanks N,Nakamoto B,Shiramizu BT,Shikuma CM

更新日期：2014-12-01 00:00:00

abstract：:Crack cocaine use is associated with impaired verbal memory in HIV-infected women more than uninfected women. To understand the neural basis for this impairment, this study examined the effects of crack cocaine use on activation of the prefrontal cortex (PFC) and strategic encoding during a verbal memory task in HIV-i...

journal_title：Journal of neurovirology

authors： Meyer VJ,Little DM,Fitzgerald DA,Sundermann EE,Rubin LH,Martin EM,Weber KM,Cohen MH,Maki PM

更新日期：2014-08-01 00:00:00

abstract：:Cognitive and functional neural correlates of human immunodeficiency virus (HIV) are only partially understood at present. Variability in neural response, which has been noted in the literature, may relate to clinical factors associated with HIV, including time since HIV diagnosis, CD4 count and nadir, HIV viral load,...

journal_title：Journal of neurovirology

authors： Caldwell JZ,Gongvatana A,Navia BA,Sweet LH,Tashima K,Ding M,Cohen RA

更新日期：2014-08-01 00:00:00

abstract：:Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the s...

journal_title：Journal of neurovirology

authors： Coughlin JM,Wang Y,Ma S,Yue C,Kim PK,Adams AV,Roosa HV,Gage KL,Stathis M,Rais R,Rojas C,McGlothan JL,Watkins CC,Sacktor N,Guilarte TR,Zhou Y,Sawa A,Slusher BS,Caffo B,Kassiou M,Endres CJ,Pomper MG

更新日期：2014-06-01 00:00:00

abstract：:Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatm...

journal_title：Journal of neurovirology

authors： Keltner JR,Fennema-Notestine C,Vaida F,Wang D,Franklin DR,Dworkin RH,Sanders C,McCutchan JA,Archibald SL,Miller DJ,Kesidis G,Cushman C,Kim SM,Abramson I,Taylor MJ,Theilmann RJ,Julaton MD,Notestine RJ,Corkran S,Chern

更新日期：2014-06-01 00:00:00

abstract：:Neurocognitive disorders such as dementia and cognitive/motor impairments are among the most significant complications associated with human immunodeficiency virus (HIV) infection, especially in aging populations, yet the pathogenesis remains poorly understood. Activated macrophages and microglia in white matter along...

journal_title：Journal of neurovirology

authors： Harbison C,Zhuang K,Gettie A,Blanchard J,Knight H,Didier P,Cheng-Mayer C,Westmoreland S

更新日期：2014-02-01 00:00:00

abstract：:Human parechoviruses (HPeV) are classified into 14 genotypes. HPeV1 and HPeV2 are the most prevalent genotypes in young children, which have been associated with mild to severe diseases. This study was conducted to investigate the involvement of HPeVs in aseptic meningitis and sepsis-like illness in Iran. Viral RNA wa...

journal_title：Journal of neurovirology

authors： Rahimi P,Naser HM,Siadat SD,Sohrabi A,Mostafavi E,Motamedirad M,Bahramali G,Sadat SM,Ardestani MS

更新日期：2013-12-01 00:00:00

abstract：:The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35-70 % of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies hav...

journal_title：Journal of neurovirology

authors： Becker KM,Heinrichs-Graham E,Fox HS,Robertson KR,Sandkovsky U,O'Neill J,Swindells S,Wilson TW

更新日期：2013-12-01 00:00:00

abstract：:There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory n...

journal_title：Journal of neurovirology

authors： Velandia-Romero ML,Castellanos JE,Martínez-Gutiérrez M

更新日期：2013-08-20 00:00:00

abstract：:Although HIV-associated dementia (HAD) occurs in less than 5 % of individuals with access to combination antiretroviral therapy, rates of milder forms of HIV-associated neurocognitive disorder (HAND) are much higher. We sought to define an optimal cut point for the International HIV Dementia Scale (IHDS) in Thailand f...

journal_title：Journal of neurovirology

authors： Chalermchai T,Valcour V,Sithinamsuwan P,Pinyakorn S,Clifford D,Paul RH,Tipsuk S,Fletcher JL,Degruttola V,Ratto-Kim S,Hutchings N,Shikuma C,Ananworanich J,SEARCH 007 and 011 study groups.

更新日期：2013-04-01 00:00:00

abstract：:In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the "Global NeuroAIDS Roundtable" in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought toge...

journal_title：Journal of neurovirology

authors： Joseph J,Achim CL,Boivin MJ,Brew BJ,Clifford DB,Colosi DA,Ellis RJ,Heaton RK,Gallo-Diop A,Grant I,Kanmogne GD,Kumar M,Letendre S,Marcotte TD,Nath A,Pardo CA,Paul RH,Pulliam L,Robertson K,Royal W 3rd,Sacktor N,Si

更新日期：2013-02-01 00:00:00

abstract：:HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established ...

journal_title：Journal of neurovirology

authors： Zhu T,Zhong J,Hu R,Tivarus M,Ekholm S,Harezlak J,Ombao H,Navia B,Cohen R,Schifitto G

更新日期：2013-02-01 00:00:00

abstract：:In Nigeria, the incidence and prevalence of human immunodeficiency virus (HIV)-related neurocognitive impairment (NCI) are unknown and there currently exists little information related to the viral correlates rates of NCI. Therefore, studies were performed to examine the potential utility of applying an established ne...

journal_title：Journal of neurovirology

authors： Royal W 3rd,Cherner M,Carr J,Habib AG,Akomolafe A,Abimiku A,Charurat M,Farley J,Oluyemisi A,Mamadu I,Johnson J,Ellis R,McCutchan JA,Grant I,Blattner WA

更新日期：2012-06-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the neurotropic human polyomavirus JC (JCV) lytic infection of oligodendrocytes. PML was first described as a complication of lymphoproliferative disorders more than 50 years ago and emerged as a major c...

journal_title：Journal of neurovirology

authors： Bellizzi A,Nardis C,Anzivino E,Rodìo D,Fioriti D,Mischitelli M,Chiarini F,Pietropaolo V

更新日期：2012-02-01 00:00:00

abstract：:Clinical or laboratory evidence of varicella-zoster virus (VZV) infection has been consistently associated with lower glioma risk in case-control studies, suggesting a protective effect of VZV against glioma. We formulated the following explanatory hypotheses: reactivated VZV preferentially infects and kills gliomas c...

journal_title：Journal of neurovirology

authors： Canniff J,Donson AM,Foreman NK,Weinberg A

更新日期：2011-10-01 00:00:00

abstract：:Recent reports suggest that a growing number of human immunodeficiency virus (HIV)-infected persons show signs of persistent cognitive impairment even in the context of combination antiretroviral therapies (cART). The basis for this finding remains poorly understood as there are only a limited number of studies examin...

journal_title：Journal of neurovirology

authors： Tate DF,Sampat M,Harezlak J,Fiecas M,Hogan J,Dewey J,McCaffrey D,Branson D,Russell T,Conley J,Taylor M,Schifitto G,Zhong J,Daar ES,Alger J,Brown M,Singer E,Campbell T,McMahon D,Tso Y,Matesan J,Letendre S,Paulo

更新日期：2011-08-01 00:00:00